The number of Twitter followers clearly indicates the popularity of a particular person and taking this into account, majority of the Twitter users try to get as many as followers as possible. It is always good to have a high number of follower count in Twitter, but what is the use if majority of them are bots or artificially attained followers.
If a Twitter user is really popular in his niche, then he is sure to get followers naturally, rather than going after various methods of getting followers. So the best Twitter profile is that which has got a good number of followers in the natural way and such types of Twitter profiles are the ones that are to be followed by us. Consider that we are following a profile which shows a huge number of followers and majority of them are bots or are not naturally obtained ones. Here you would not be getting any benefit of following such a user as even if he shares your posts, it would vanish somewhere without being re-shared by his followers.
On the other hand if you are following a profile which has genuine followers that are obtained naturally, then the chances are that if he shares any of your tweets, it has got a higher chance of getting re-tweeted by his followers as most of them are genuine and might be more active. So before following any Twitter profile based on the count of its followers, make sure that the user has created such a number of followers in the natural way and they are authentic.